The course is addressed to PhD students and postdoctoral researchers in mechanical and civil engineering, applied mathematics, physics, biomedical engineering, bioengineering, physiology and materials science interested in broadening their knowledge in the area of biomechanical modelling, and to senior scientists and engineers including some from relevant industries. Armed with sophisticated computational tools, researchers are seeking answers to fundamental questions by exploring complex biomechanical phenomena at the molecular, cellular, tissue and organ levels. Particular attention is focused on microstructural and multi-scale modeling, finite element implementation and simulation of cells and tissues. Ogden: Anisotropy and Nonlinear Elasticity in Arterial Wall MechanicsG. The course will include lectures on the importance of the nanoscale to the strength of natural materials, and focuses on the underlying molecular mechanisms of natural composite biological materials and their interactions at the molecular level in order to understand their crucial influence on, for example, growth.
Glaucoma, Second Edition is the most comprehensive resource in the field delivering expert guidance for the most timely and effective diagnosis and treatment of glaucoma — aimed at specialists, fellows and general ophthalmologists. Polish Academy of Sciences: Warsaw, Poland. Humphrey: Need for a Continuum Biochemomechanical Theory of Soft Tissue and Cellular Growth and Remodeling H. The models in Part I illustrate the importance of quantitative approaches for gaining a deeper understanding of how normal and abnormal aspects of signal integration culminate in the cell proliferation, migration, and survival decisions that result in pathological tumor angiogenesis. A major challenge facing the cancer research community is to integrate known information in a way that improves our understanding of the principal underpinnings driving tumor angiogenesis and that will advance efforts aimed at the development of new therapies for treating cancer. Book Sections 2017 In: Holzapfel, G. Successful angiogenesis is mediated by the intricate interplay between biochemical and biomechanical mechanisms, including cell-cell and cell-matrix interactions, cell surface receptor binding, and intracellular signal transduction.
Holzapfel: Arterial Tissue in Health and Disease: Experimental Data, Collagen-based Modeling and Simulation, Including Aortic Dissection. Humphrey: Need for a Continuum Biochemomechanical Theory of Soft Tissue and Cellular Growth and Remodeling H. Biomechanics is closely related to engineering, because it often uses traditional engineering sciences to analyze biological systems. The E-mail message field is required. This provides a rational basis for applications to, for example, i tissue engineering, ii the design and development of tissue prosthetics, and iii the improvement of diagnostics and therapeutical procedures that involve tissue mechanics. It presents a review of the current knowledge of the behaviour of soft tissues in the cardiovascular system under mechanical loads, and the importance of constitutive laws in understanding the underlying mechanics is highlighted. These two processes strongly depend on one another in ways that can only be theoretically investigated by biophysical approaches that cut across several levels of biological organization and describe both the tumor and the developing vasculature as they co-evolve.
Applied mechanics, most notably mechanical engineering disciplines such as continuum mechanics, mechanism analysis, structural analysis, kinematics and dynamics play prominent roles in the study of biomechanics. The A01s of the various papers contained in this work were asked to be provocative and to force the readers out of their comfort zone of thinking about stem cells in the breast and in breast cancer. The mechanics of the whole cell and sub-cellular components as well as the extracellular matrix structure and mechanotransduction are described. This includes experimental, continuum mechanical and computational perspectives, with the emphasis on nonlinear behaviour, and the simulation of mechanical procedures such as balloon angioplasty. The book serves as an invaluable source of information for researchers, instructors and advanced undergraduate and graduate students interested in systems biology, applied mathematics and biomedical engineering. Waves in Nonlinear Pre-stressed Materials. Mechanics and Thermomechanics of Rubberlike Solids.
Holzapfel: Arterial Tissue in Health and Disease: Experimental Data, Collagen-based Modeling and Simulation, Including Aortic Dissection. Hunter: Multi-scale Modelling of the Heart R. It develops the reader's understanding of and intuition for multiscale phenomena in biomechanics and mechanobiology, and introduces a mathematical framework and computational techniques paramount to creating predictive multiscale models. The articles in this publication explore fundamental questions of the origin, evolution and properties of the stem cell in normal as well as cancerous tissue. A theoretical framework for this process will be developed and explained taking account of the separate contributions of the constituents such as actin, intermediate filaments, and microtubules.
Polish Academy of Sciences: Warsaw, Poland. Humphrey: Need for a Continuum Biochemomechanical Theory of SoftTissue and Cellular Growth and RemodelingH. Glean all essential, up-to-date, need-to-know information about stem cell research, gene transfer, and implants. Contents: Need for a Continuum Biochemomechanical Theory of Soft Tissue and Cellular Growth and Remodeling -- Multi-scale Modelling of the Heart -- Anisotropy and Nonlinear Elasticity in Arterial Wall Mechanics -- Arterial Tissue in Health and Disease: Experimental Data, Collagen-Based Modeling and Simulation, Including Aortic Dissection. The computational armamentarium includes such diverse tools as the ab initio quantum mechanical and molecular dynamics methods at the atomistic scales and the finite element, boundary element, meshfree as well as immersed boundary and lattice-Boltzmann methods at the continuum scales.
The course also includes passive and active cardiac mechanics by focusing on the histological structure of the heart wall, on an orthotropic microstructurally-based constitutive model for the myocardium, on remodelling phenomena and on a three-dimensional finite element model of the heart, which aims to accurately predict the mechanical changes in the left and right ventricular myocardia during the cardiac cycle. Series: London Mathematical Society lecture note series 283. Mechanics and Electrodynamics of Magneto- and Electro-elastic Materials. Nonlinear Elasticity: Theory and Applications. After a brief overview of the anatomy, physiology and biomechanics of the uterus, the authors focus mainly on electromechanical wave processes, their origin, dynamics, and neuroendocrine and pharmacological modulations. Series: Balkema-proceedings and monographs in engineering, water, and earth sciences. Hunter: Multi-scale Modelling of the Heart R.
While most applications require forward analysis, e. The volume focuses on the evolution of the many families of genes whose products are required to make a particular kind of polysaccharide, bringing attention to the specific biochemical properties of the proteins to the level of kinds of sugar linkages they make. The part on arterial tissue modelling in health and disease will focus on providing a basis for the implementation of mechanical models in numerical codes. All libraries in universities and research establishments where plant sciences, agriculture, biological, biochemical and molecular sciences are studied and taught should have copies of this important volume. Series: Studies in Mechanobiology, Tissue Engineering and Biomaterials 20.
Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. The use of mathematical models to describe various aspects of tumor growth has a very long history, dating back over six decades. Holzapfel: Arterial Tissue in Health and Disease: Experimental Data, Collagen-based Modeling and Simulation, Including Aortic Dissection. The lectures continue with a general theoretical framework for the description of growth and remodelling in biological tissues. A collection of exercises is added at the end of each chapter to help readers with self-evaluation.