Evolutionary biology of aging rose michael r. Evolutionary Biology of Aging : Michael R. Rose : 9780195095302 2019-02-01

Evolutionary biology of aging rose michael r Rating: 5,4/10 1095 reviews

Evolutionary biology of aging

evolutionary biology of aging rose michael r

Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. An Evolutionary Perspective on Organismal Theories of Aging 7. The proposed theory is that to understand aging we must understand its evolution; only then do its taxonomic distribution and its genetic and physiological mechanisms become intelligible. Evolutionary biologists, gerontologists, and all those concerned with the science of aging will find it a stimulating, strongly argued account. Lastly, we will consider research on the cessation of aging, a recently uncovered phenomenon of great interest from an evolutionary standpoint. A serious and sustained attempt to change the basis, content, and direction of a whole discipline. Evidence is produced from the fields of cell biology, physiology, and gerontology.

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Evolutionary Biology of Aging

evolutionary biology of aging rose michael r

A serious and sustained attempt to change the basis, content, and direction of a whole discipline. The evolutionary theory of ageing; observation of ageing; experimental tests of the evolutionary theory of ageing; genetic mechanisms form the evolution of ageing; comparative biology of ageing; an evolutionary perspective on organismal theories of ageing; an evolutionary perspective on cellular and molecular theories of ageing; the future of gerontology. The author ably surveys the vast literature on aging, presenting mathematical, experimental, and comparative findings to illustrate and support the central thesis. The long-lived flies show other weaknesses that would make them poor competitors in the wild, and perhaps these traits are the true areas of antagonistic pleiotropy. Users without a subscription are not able to see the full content on this page. This theory in turn yields the most fruitful avenues for seeking answers to the problem of aging, and should be recognized as the intellectual core of gerontology and the foundation for future research.

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9780195061338: Evolutionary Biology of Aging

evolutionary biology of aging rose michael r

Evidence is produced from the fields of cell biology, physiology, and gerontology. The forgoing of immortality might make additional resources available to reproductive cells. The evolutionary theory of aging; Observation of aging; Experimental tests of the evolutionary theory of aging; Genetic mechanisms form the evolution of aging; Comparative biology of aging; An evolutionary perspective on organismal theories of aging; An evolutionary perspective on cellular and molecular theories of aging; The future of gerontology. The genes are favored by natural selection as a result of their early-life benefits, and the costs that accrue much later appear as incidental side-effects that we identify as aging. Rose himself is a leader in this field, his work on genetics of aging in Drosophilia having become a classic demonstration both of age-specific gene effects on survival and fertility and of genes with opposing effects on fitness at different ages. This relies too much on to.

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9780195061338: Evolutionary Biology of Aging

evolutionary biology of aging rose michael r

Certainly, there is nothing else available that so adequately brings together the evolutionary theories of aging and so competently evaluates them. Digital Library Federation, December 2002. In humans, the 'late-life' stage of life is only reached at 90 years old, whereas the data for flies scaled to humans would predict a 'late-life' stage for humans at 40—50 years old. The proposed theory is that to understand aging we must understand its evolution; only then do its taxonomic distribution and its genetic and physiological mechanisms become intelligible. Comparative Biology of Aging 6. This volume published in 1891 contains three key essays delivered in the early 1880s.

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Evolutionary Biology of Ageing : Michael R. Rose : 9780195061338

evolutionary biology of aging rose michael r

Fruit flies are being bred for longevity by collecting eggs from the longest-lived flies in each generation. We will touch on the quantitative genetics of aging and its manipulation using experimental evolution. In 1997, Rose was awarded the Busse Research Prize by the World Congress of Gerontology. It is clearly and concisely written by one who has achieved eminence both as a theoretician and as an experimenter. They also assess the research in the field of aging from an evolutionary and cellular standpoint.

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Michael R. Rose

evolutionary biology of aging rose michael r

Weismann proposed limits to somatic cell replication as a mechanism for this inability to heal. Rose contends that a correct understanding of Hamilton's equations through mathematical modeling show that protagonistic pleiotropy is plausible. The basis for this approach lies in the fact that natural selection, as a powerful determining force, tends to decline in importance with age. Rose suggests that if a decline in the effect of natural selection is responsible for aging, then when this decline finally ends, at post-reproductive age, aging could halt. He produces an excellent review of the current state of knowledge on this point, not only for the classic animal models for work on aging, 'the' nematode, fruit fly, and mouse, but also for lesser-known breeds including plants. About the Author: Michael R.

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Evolutionary biology of aging (eBook, 1991) [dawailelo.com]

evolutionary biology of aging rose michael r

Experimental Evolution: Concepts, Methods, and Applications of Selection Experiments. His proposed explanation is that at a stage of life beyond the potential to reproduce, the effect of natural selection is no longer falling as it has 'bottomed out'. Over the last forty years this field has developed important empirical foundations. Useful and well worth its price. Essays upon heredity and kindred biological problems. This unique book looks at the biology of aging from a fundamentally new perspective, one based on evolutionary theory rather than traditional concepts which emphasize molecular and cellular processes. Older individuals would therefore take limited resources that could be better allocated to younger individuals, thus creating a selective advantage at the level of the population or group for dying at old ages.

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Evolutionary Biology of Aging by Michael R. Rose

evolutionary biology of aging rose michael r

Contentious material about living persons that is unsourced or poorly sourced must be removed immediately, especially if potentially or harmful. The result is the first complete synthesis of this vital field. Many of the characteristics we associate with aging, the author argues, are more the result of this decline than any mechanical imperative contained within organic structures. This review is more than competent and fills a long empty space on the evolutionary biological bookshelf. From now on gerontological research will be 'after Rose'.

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Evolutionary Biology of Aging

evolutionary biology of aging rose michael r

This theory in turn yields the most fruitful avenues for seeking answers to the problem of aging, and should be recognized as the intellectual core of gerontology and the foundation for future research. The result has been the opposite - that the long-lived flies actually lay more eggs at every stage of life. Rose suggests that human populations' adoption of agriculture led to more children surviving to adulthood, and to reproduction occurring later in life. Agriculture is also hypothesized by Rose to have resulted in high population density, thereby increasing the range of ages not under selection. According to Rose, mortality-rate plateaus have not often been noticed in humans because they are only seen in specific-age cohorts of the very old.

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Evolutionary biology of aging (eBook, 1991) [dawailelo.com]

evolutionary biology of aging rose michael r

Evolutionary biologists, gerontologists, and all those concerned with the science of aging will find it a stimulating, strongly argued account. Contents: The Evolutionary Theory of Aging -- Observation of Aging -- Experimental Tests of the Evolutionary Theory of Aging -- Genetic Mechanisms for the Evolution of Aging -- Comparative Biology of Aging -- An Evolutionary Perspective on Organismal Theories of Aging -- An Evolutionary Perspective on Cellular and Molecular Theories of Aging -- The Future of Gerontology. The proposed theory is that to understand aging we must understand its evolution; only then do its taxonomic distribution and its genetic and physiological mechanisms become intelligible. Experimental Tests of the Evolutionary Theory of Aging 4. Protagonistic pleiotropy is the opposite effect: beneficial effects in later life as a result of selection for reproduction in earlier life. This review is more than competent and fills a long empty space on the evolutionary biological bookshelf. This unique book looks at the biology of aging from a fundamentally new perspective, one based on evolutionary theory rather than traditional concepts which emphasize molecular and cellular processes.

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